1 - The finest example of Byzantine architecture is the church of Saint Sophia (Holy Wisdom) in İstanbul, constructed by the emperor Justinian in the sixth century.

2 - Mecca is considered to be the most important and holy city in the world to Muslims, followers of the Islamic religion, because they believe that Mecca was the first place on earth that God created.

3 - By the 14th century, the Holy Roman Empire was little more than a loose federation of the German princes who elected the Holy Roman emperor.

4 - During the holy month of Ramadan, devout Muslims abstain from food, drink and smoking during daylight hours as an act of sacrifice.

5 - Finding a successful treatment for obesity would be a Holy Grail for scientists.